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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rps6ka2tm1.1Mskf
targeted mutation 1.1, Michael S Kapiloff
MGI:5544762
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rps6ka2tm1.1Mskf/Rps6ka2tm1.1Mskf B6.129(C)-Rps6ka2tm1.1Mskf MGI:5544778


Genotype
MGI:5544778
hm1
Allelic
Composition
Rps6ka2tm1.1Mskf/Rps6ka2tm1.1Mskf
Genetic
Background
B6.129(C)-Rps6ka2tm1.1Mskf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps6ka2tm1.1Mskf mutation (0 available); any Rps6ka2 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• prior to stress, mice exhibit normal cardiac function
• following transverse aortic constriction, mice exhibit reduced increase in myocyte transverse cross-section area compared with wild-type mice
• following transverse aortic constriction, mice exhibit less of an increase in posterior wall thickness and biventricular weight compared with wild-type mice
• following transverse aortic constriction, mice exhibit less of an increase in posterior wall thickness and biventricular weight with reduced increase in myocyte transverse cross-section area compared with wild-type mice
• however, contractile shortening is the same as in wild-type mice and mice exhibit normal cardiac response to exercise

homeostasis/metabolism
• following transverse aortic constriction, mice exhibit less of an increase in posterior wall thickness and biventricular weight with reduced increase in myocyte transverse cross-section area compared with wild-type mice
• however, contractile shortening is the same as in wild-type mice and mice exhibit normal cardiac response to exercise

muscle
• following transverse aortic constriction, mice exhibit reduced increase in myocyte transverse cross-section area compared with wild-type mice





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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory