Analysis Tools
mortality/aging
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• all mice die tween E10.5 and E12.5
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reproductive system
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• at E10.5, all mice exhibit smaller labyrinth/implantation sites compared with wild-type mice
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embryo
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• less developed
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• decreased somite number at E10.5
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• in all mice
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• reduced cells in all mice
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• limited branching morphogenesis of the labyrinth
• at E10.5, all mice exhibit smaller labyrinth/implantation sites compared with wild-type mice
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• in 11 of 19 mice
• however, mice exhibit normal endoderm and mesoderm in the yolk sac vasculature
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• failure of chorioallantoic attachment in 7 of 19 mice at E10.5
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cardiovascular system
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• in 10 of 19 mice at E10.5
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• under-developed in some mice at E10.5
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• in some mice at E10.5
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• thin and less trabeculated at E10.5
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craniofacial
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• in 4 of 19 mice at E10.5
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nervous system
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• less developed
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• less developed
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growth/size/body
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• reduced crown rump length
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