Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbkbp1tm1Aki mutation
(0 available);
any
Tbkbp1 mutation
(23 available)
|
|
|
hematopoietic system
N |
• macrophages and GM-CSF-derived bone marrow-derived dendritic cells exhibit normal cytokine responses after retinoic acid-induction gene-I-like receptor (RLR) and TLR stimulation
• bone marrow cells proliferate normally in GM-CSF culture
|
immune system
N |
• macrophages and GM-CSF-derived bone marrow-derived dendritic cells exhibit normal cytokine responses after retinoic acid-induction gene-I-like receptor (RLR) and TLR stimulation
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Azi2tm1Aki mutation
(0 available);
any
Azi2 mutation
(30 available)
Tbkbp1tm1Aki mutation
(0 available);
any
Tbkbp1 mutation
(23 available)
|
|
|
immune system
N |
• macrophages exhibit normal cytokine responses after retinoic acid-induction gene-I-like receptor (RLR) and TLR stimulation
|
|
• GM-CSF-derived bone marrow-derived dendritic cells stimulated with TLR ligands (including poly(I:C), LPS and CpG DNA) or infection with RNA viruses (including NDV, Flu and EMCV) exhibit impaired IL6 and TNF production compared with wild-type mice
• GM-CSF-derived bone marrow-derived dendritic cells stimulated with NDV infection exhibit reduced IFN-alpha production compared with wild-type cells
|
|
• in GM-CSF-derived bone marrow-derived dendritic cells stimulated with NDV infection
|
|
• in GM-CSF-derived bone marrow-derived dendritic cells stimulated with TLR ligands (including poly(I:C), LPS and CpG DNA) or infection with RNA viruses (including NDV, Flu and EMCV)
|
|
• in GM-CSF-derived bone marrow-derived dendritic cells stimulated with TLR ligands (including poly(I:C), LPS and CpG DNA) or infection with RNA viruses (including NDV, Flu and EMCV)
|