Phenotypes associated with this allele

• Allele Symbol: Ryr1^tm2.1Itl
• Allele Name: targeted mutation 2.1, inGenious Targeting Laboratory
• Allele ID: MGI:5544310
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Ryr1^tm2.1Itl/?	B6.Cg-Ryr1^tm2.1Itl	MGI:5544311

Genotype
MGI:5544311

ot1

• Allelic Composition: Ryr1^tm2.1Itl/?
• Genetic Background: B6.Cg-Ryr1^tm2.1Itl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

muscle phenotype ( J:205099 )

N • mice exhibit normal skeletal muscle histology and baseline fast twitch force generation

abnormal skeletal muscle fiber morphology ( J:205099 )

• isoproterenol treated muscles fail to exhibit an increase in calcium transients compared with wild-type muscles

abnormal muscle physiology ( J:205099 )

• treatment with isoproterenol fails to increase twitch force as in wild-type mice

• isoproterenol treated muscle exhibit slower rate of twitch force development compared with wild-type muscle

• however, half-relaxation time is normal following isoproterenol treatment

behavior/neurological

decreased grip strength ( J:205099 )