Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-Yap1*S112A)#Eno
• Allele Name: transgene insertion, Eric N Olson
• Allele ID: MGI:5544294
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-Yap1*S112A)#Eno/0	involves: C3H * C57BL/6	MGI:5544301

Genotype
MGI:5544301

tg1

• Allelic Composition: Tg(Myh6-Yap1*S112A)#Eno/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Enhanced cardiac regeneration in Tg(Myh6-Yap1*S112A)#Eno/0 mice

cardiovascular system

thick myocardium ( J:200670 )

increased heart weight ( J:200670 )

abnormal cardiovascular system physiology ( J:200670 )

• cardiac function after permanent ligation of the left anterior descending coronary artery is improved compared to wild-type controls

abnormal myocardial fiber physiology ( J:200670 )

• increase in proliferation at P7 and in adults

decreased cardiomyocyte apoptosis ( J:200670 )

• after permanent ligation of the left anterior descending coronary artery at 4 weeks of age

decreased myocardial infarct size ( J:200670 )

• 21 days after permanent ligation of the left anterior descending coronary artery at P7, hearts are regenerated with minimal fibrosis unlike wild-type controls that show extensive scarring, loss of myocardial tissue, and ventricular dilation

• 7 or 21 days after permanent ligation of the left anterior descending coronary artery at P28, fibrosis is reduced and myocardial tissue is increased compared to wild-type controls

growth/size/body

increased heart weight ( J:200670 )

muscle

thick myocardium ( J:200670 )

decreased cardiomyocyte apoptosis ( J:200670 )

• after permanent ligation of the left anterior descending coronary artery at 4 weeks of age

enhanced cardiac muscle regeneration ( J:200670 )

• enhanced cardiac regeneration after permanent ligation of the left anterior descending coronary artery at P7 and P21

homeostasis/metabolism

decreased myocardial infarct size ( J:200670 )

• 21 days after permanent ligation of the left anterior descending coronary artery at P7, hearts are regenerated with minimal fibrosis unlike wild-type controls that show extensive scarring, loss of myocardial tissue, and ventricular dilation

• 7 or 21 days after permanent ligation of the left anterior descending coronary artery at P28, fibrosis is reduced and myocardial tissue is increased compared to wild-type controls

cellular

decreased cardiomyocyte apoptosis ( J:200670 )

• after permanent ligation of the left anterior descending coronary artery at 4 weeks of age