All Phenotypes Gjd3<tm2.1Kwi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gjd3^tm2.1Kwi
targeted mutation 2.1, Klaus Willecke
MGI:5544288

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gjd3^tm2.1Kwi/Gjd3^tm2.1Kwi	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5544302
cn2	Gjc1^tm1Kwi/Gjc1^tm1Kwi Gjd3^tm2.1Kwi/Gjd3^tm2.1Kwi Tg(Myh6-icre/ERT2)#Wet/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL	MGI:5544303

Allelic Composition	Gjd3^tm2.1Kwi/Gjd3^tm2.1Kwi
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gjd3^tm2.1Kwi mutation (1 available); any Gjd3 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:205110 )

N	• mice are viable

cardiovascular system

cardiovascular system phenotype ( J:205110 )

N	• mice exhibit normal heart morphology, equal heart rates, P-wave duration, QRS intervals and QTc intervals without spontaneous AV block, supraventricular or ventricular ectopic beats or arrhythmia

abnormal heart electrocardiography waveform feature ( J:205110 )

• tamoxifen-treated mice exhibit shortened atria-His (AH) interval and Wenckebach periodicity compared with control mice

shortened PR interval ( J:205110 )

Allelic Composition	Gjc1^tm1Kwi/Gjc1^tm1Kwi Gjd3^tm2.1Kwi/Gjd3^tm2.1Kwi Tg(Myh6-icre/ERT2)#Wet/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gjc1^tm1Kwi mutation (1 available); any Gjc1 mutation (33 available)
Gjd3^tm2.1Kwi mutation (1 available); any Gjd3 mutation (13 available)
Tg(Myh6-icre/ERT2)#Wet mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:205110 )

N	• tamoxifen-treated mice are viable

cardiovascular system

cardiovascular system phenotype ( J:205110 )

N	• tamoxifen-treated mice exhibit normal heart morphology, equal heart rates, P-wave duration, QRS intervals and QTc intervals without spontaneous AV block, supraventricular or ventricular ectopic beats or arrhythmia

abnormal heart electrocardiography waveform feature ( J:205110 )

• tamoxifen-treated mice exhibit prolonged atria-His (AH) interval and Wenckebach periodicity compared with control mice

prolonged PQ interval ( J:205110 )

• in tamoxifen-treated mice

abnormal sinoatrial node conduction ( J:205110 )

• tamoxifen-treated mice exhibit shorter sinus node recovery rate compared with control mice

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