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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pon3tm1Lus
targeted mutation 1, Aldons J Lusis
MGI:5544271
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pon3tm1Lus/Pon3tm1Lus involves: 129X1/SvJ MGI:5544272


Genotype
MGI:5544272
hm1
Allelic
Composition		 Pon3tm1Lus/Pon3tm1Lus
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pon3tm1Lus mutation (1 available); any Pon3 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
oxidative stress ( J:204799 )
• after antimycin A treatment, liver mitochondria superoxide levels are increased while glutathione levels are decreased compared to in wild-type mitochondria

homeostasis/metabolism
decreased glutathione level ( J:204799 )
• in liver mitochondria after antimycin A treatment




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory