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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gja5tm2.1Kwi
targeted mutation 2.1, Klaus Willecke
MGI:5544269
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gja5tm2.1Kwi/Gja5tm2.1Kwi involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:5544270


Genotype
MGI:5544270
hm1
Allelic
Composition		 Gja5tm2.1Kwi/Gja5tm2.1Kwi
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja5tm2.1Kwi mutation (1 available); any Gja5 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased mean systemic arterial blood pressure ( J:205109 )
• when fed a normal salt diet
• however, mice fed a low salt diet in combination with ACE inhibitor enalapril treatment exhibit normal blood pressure

homeostasis/metabolism
increased circulating renin level ( J:205109 )
• basal levels are increased 6-fold




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory