Phenotypes associated with this allele

• Allele Symbol: Tg(Amh-SMAD2*)#Jebu
• Allele Name: transgene insertion, Joanna E Burdette
• Allele ID: MGI:5543909
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(Amh-SMAD2*)#Jebu/0 Trp53^tm1Brn/Trp53^tm1Brn	involves: 129P2/OlaHsd * FVB/N	MGI:5543911
tg2	Tg(Amh-SMAD2*)#Jebu/0	FVB/N-Tg(Amh-SMAD2*)#Jebu	MGI:5543910

Genotype
MGI:5543911

cn1

• Allelic Composition: Tg(Amh-SMAD2*)#Jebu/0; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

ovary cyst ( J:200783 )

♀ • 1 of 7 mice injected with an adenovirus expressing cre recombinase into the bursa develop fluid-filled bursal cysts 6 months after injection

♀ • however, mice injected with an adenovirus expressing cre recombinase into the oviduct exhibit no change in phenotype 3 or 6 months after injection

increased ovarian teratoma incidence ( J:200783 )

♀ • 2 of 6 mice injected with an adenovirus expressing cre recombinase into the bursa develop teratoma 3 months after injection

reproductive system

ovary cyst ( J:200783 )

♀ • 1 of 7 mice injected with an adenovirus expressing cre recombinase into the bursa develop fluid-filled bursal cysts 6 months after injection

♀ • however, mice injected with an adenovirus expressing cre recombinase into the oviduct exhibit no change in phenotype 3 or 6 months after injection

increased ovarian teratoma incidence ( J:200783 )

♀ • 2 of 6 mice injected with an adenovirus expressing cre recombinase into the bursa develop teratoma 3 months after injection

neoplasm

increased ovarian teratoma incidence ( J:200783 )

♀ • 2 of 6 mice injected with an adenovirus expressing cre recombinase into the bursa develop teratoma 3 months after injection

growth/size/body

ovary cyst ( J:200783 )

♀ • 1 of 7 mice injected with an adenovirus expressing cre recombinase into the bursa develop fluid-filled bursal cysts 6 months after injection

♀ • however, mice injected with an adenovirus expressing cre recombinase into the oviduct exhibit no change in phenotype 3 or 6 months after injection

Genotype
MGI:5543910

tg2

• Allelic Composition: Tg(Amh-SMAD2*)#Jebu/0
• Genetic Background: FVB/N-Tg(Amh-SMAD2*)#Jebu

endocrine/exocrine glands

ovary cyst ( J:200783 )

♀ • mutants develop ovarian inclusion cysts; mice that only develop inclusion cysts show low transgene expression

increased ovary tumor incidence ( J:200783 )

♀ • 3 of 18 mutants exhibit abnormal tumor-like ovaries at 8 weeks of age, with tumors showing some, but not all the characteristics of the mature teratomas

increased ovarian teratoma incidence ( J:200783 )

♀ • 5 of 18 mutants develop ovarian teratomas at 2-6 months of age, some of which appear malignant; mice that develop teratomas show high transgene expression

♀ • teratomas are characterized by areas of invasive, undifferentiated cells and inclusion cysts lined with ciliated cells reminiscent of oviductal or respiratory epithelium

♀ • 3 of the tumors contain squamous cell-lined cysts filled with keratin and well-to-moderately differentiated invasive squamous cells and nervous tissue-like areas

♀ • fat, blood-filled spaces, calcified bone and cartilage formation, and thyroid gland-like structures are seen in some teratomas

♀ • by 6 months of age, teratomas are about 10 times the size of a normal ovary, do not show normal follicular or ovarian structures, and contain many highly proliferative epithelium-lined inclusion cysts

reproductive system

ovary cyst ( J:200783 )

♀ • mutants develop ovarian inclusion cysts; mice that only develop inclusion cysts show low transgene expression

increased ovary tumor incidence ( J:200783 )

♀ • 3 of 18 mutants exhibit abnormal tumor-like ovaries at 8 weeks of age, with tumors showing some, but not all the characteristics of the mature teratomas

increased ovarian teratoma incidence ( J:200783 )

♀ • 5 of 18 mutants develop ovarian teratomas at 2-6 months of age, some of which appear malignant; mice that develop teratomas show high transgene expression

♀ • teratomas are characterized by areas of invasive, undifferentiated cells and inclusion cysts lined with ciliated cells reminiscent of oviductal or respiratory epithelium

♀ • 3 of the tumors contain squamous cell-lined cysts filled with keratin and well-to-moderately differentiated invasive squamous cells and nervous tissue-like areas

♀ • fat, blood-filled spaces, calcified bone and cartilage formation, and thyroid gland-like structures are seen in some teratomas

♀ • by 6 months of age, teratomas are about 10 times the size of a normal ovary, do not show normal follicular or ovarian structures, and contain many highly proliferative epithelium-lined inclusion cysts

neoplasm

increased ovary tumor incidence ( J:200783 )

♀ • 3 of 18 mutants exhibit abnormal tumor-like ovaries at 8 weeks of age, with tumors showing some, but not all the characteristics of the mature teratomas

increased ovarian teratoma incidence ( J:200783 )

♀ • 5 of 18 mutants develop ovarian teratomas at 2-6 months of age, some of which appear malignant; mice that develop teratomas show high transgene expression

♀ • teratomas are characterized by areas of invasive, undifferentiated cells and inclusion cysts lined with ciliated cells reminiscent of oviductal or respiratory epithelium

♀ • 3 of the tumors contain squamous cell-lined cysts filled with keratin and well-to-moderately differentiated invasive squamous cells and nervous tissue-like areas

♀ • fat, blood-filled spaces, calcified bone and cartilage formation, and thyroid gland-like structures are seen in some teratomas

♀ • by 6 months of age, teratomas are about 10 times the size of a normal ovary, do not show normal follicular or ovarian structures, and contain many highly proliferative epithelium-lined inclusion cysts

growth/size/body

ovary cyst ( J:200783 )

♀ • mutants develop ovarian inclusion cysts; mice that only develop inclusion cysts show low transgene expression

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dermoid cyst of ovary		DOID:5117	OMIM:166950	J:200783