Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rock1tm1.1Itl mutation
(0 available);
any
Rock1 mutation
(57 available)
|
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growth/size/body
N |
• mice exhibit normal body weight
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rock1tm1.1Itl mutation
(0 available);
any
Rock1 mutation
(57 available)
|
|
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adipose tissue
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• following injection of a cre-expressing adenovirus in the hypothalamus
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behavior/neurological
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• following injection of a cre-expressing adenovirus in the hypothalamus
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growth/size/body
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• following injection of a cre-expressing adenovirus in the hypothalamus
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rock1tm1.1Itl mutation
(0 available);
any
Rock1 mutation
(57 available)
|
|
|
cellular
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• upon starvation, mouse embryonic fibroblasts transfected with a cre-expressing adenovirus exhibit decreased LC3 punctae compared with wild-type cells
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homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rock1tm1.1Itl mutation
(0 available);
any
Rock1 mutation
(57 available)
Tg(Pomc1-cre)16Lowl mutation
(1 available)
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adipose tissue
homeostasis/metabolism
behavior/neurological
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• during the dark phase
• however, movement during the light phase is normal
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growth/size/body
skeleton
N |
• mice exhibit normal femur length, bone mineral density and bone mineral content
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rock1tm1.1Itl mutation
(0 available);
any
Rock1 mutation
(57 available)
Tg(Npy-hrGFP)1Lowl mutation
(1 available)
Tg(Pomc1-cre)16Lowl mutation
(1 available)
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nervous system
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• leptin fails to depolarize POMC+ neurons and increase firing rate unlike in control neurons
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrptm1(cre)Lowl mutation
(1 available);
any
Agrp mutation
(18 available)
Rock1tm1.1Itl mutation
(0 available);
any
Rock1 mutation
(57 available)
|
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adipose tissue
growth/size/body