Phenotypes associated with this allele

• Allele Symbol: Utf1^tm1Okud
• Allele Name: targeted mutation 1, Akihiko Okuda
• Allele ID: MGI:5543270
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Utf1^tm1Okud/Utf1^tm1Okud	B6.129P2-Utf1^tm1Okud	MGI:5543291
hm2	Utf1^tm1Okud/Utf1^tm1Okud	involves: 129P2/OlaHsd * C57BL/6J * ICR	MGI:5543292

Genotype
MGI:5543291

hm1

• Allelic Composition: Utf1^tm1Okud/Utf1^tm1Okud
• Genetic Background: B6.129P2-Utf1^tm1Okud

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Growth retardation in Utf1^tm1Okud/Utf1^tm1Okud mutants

mortality/aging

neonatal lethality, incomplete penetrance ( J:204409 )

• Background Sensitivity: most mice on a C57BL/6J congenic background die within a day after birth unlike mice on a mixed background that are viable

postnatal lethality, complete penetrance ( J:204409 )

• Background Sensitivity: mice on a C57BL/6J congenic background do not survive more than 2 days after birth unlike mice on a mixed background that are viable

embryo

small placenta ( J:204409 )

• at E14.5 due to delayed development

decreased placenta weight ( J:204409 )

• at E14.5 due to delayed development

abnormal placenta development ( J:204409 )

• delayed with reduced mitotic activity

growth/size/body

decreased birth weight ( J:204409 )

fetal growth retardation ( J:204409 )

• evident mid-gestation (E14.5 and E16.5)

cardiovascular system

thin myocardium ( J:204409 )

• at E14.5 due to delayed development

skeleton

delayed bone ossification ( J:204409 )

• delay in the replacement of cartilaginous ribs with ossified ribs at E16.5

cellular

decreased cell proliferation ( J:204409 )

• in the placenta

muscle

thin myocardium ( J:204409 )

• at E14.5 due to delayed development

Genotype
MGI:5543292

hm2

• Allelic Composition: Utf1^tm1Okud/Utf1^tm1Okud
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

mortality/aging

mortality/aging ( J:204409 )

N • Background Sensitivity: mice on a mixed background are viable unlike mice on a C57BL/6J congenic background that soon after birth

reproductive system

reproductive system phenotype ( J:204409 )

N • mice are fertile

growth/size/body

decreased body weight ( J:204409 )

• at 4 weeks