About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kittm1(cre/ERT2)Dsa
targeted mutation 1, Dieter Saur
MGI:5543260
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Kittm1(cre/ERT2)Dsa/Kit+
Prkg1tm2Naw/Prkg1tm2Naw 		involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 MGI:5545743
cn2
 		Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Kittm1(cre/ERT2)Dsa/Kit+ 		involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 MGI:5545742


Genotype
MGI:5545743
cn1
Allelic
Composition		 Kittm1(cre/ERT2)Dsa/Kit+
Prkg1tm2Naw/Prkg1tm2Naw
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kittm1(cre/ERT2)Dsa mutation (0 available); any Kit mutation (179 available)
Prkg1tm2Naw mutation (0 available); any Prkg1 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal gastrointestinal motility ( J:204737 )
• significant GI motor dysfunction is observed with tamoxifen treatment
abnormal intestinal peristalsis ( J:204737 )
• change in contraction frequency is observed in tamoxifen-treated mutants
• nitric oxide-dependent nitrergic slow component of the inhibitory junction potential in circular smooth muscle cells of the colon is abolished in tamoxifen-treated mice
abnormal intestinal transit time ( J:204737 )
• GI transit time is increased by about 2 hours in treated mutants

muscle
abnormal intestinal peristalsis ( J:204737 )
• change in contraction frequency is observed in tamoxifen-treated mutants
• nitric oxide-dependent nitrergic slow component of the inhibitory junction potential in circular smooth muscle cells of the colon is abolished in tamoxifen-treated mice




Genotype
MGI:5545742
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Kittm1(cre/ERT2)Dsa/Kit+
Genetic
Background		 involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Jpmb mutation (2 available); any Gt(ROSA)26Sor mutation (944 available)
Kittm1(cre/ERT2)Dsa mutation (0 available); any Kit mutation (179 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal gastrointestinal motility ( J:204737 )
• significantly disturbed after 3 days of tamoxifen treatment (which results in loss of more than 50% of insterstitial cells of Cajal (ICCs)
abnormal intestinal peristalsis ( J:204737 )
• tamoxifen-treated mice show dysrhythmia resulting from uncoordinated spontaneous contractions and lack of slow-wave type electrical activity
abnormal intestinal transit time ( J:204737 )
• total GI transit time is increased to more than 5 hours; similar transit time is measured in tamoxifen-treated mutants that have been repopulated with wild-type mast cells (by adaptive BM transplant)
impaired gastric peristalsis ( J:204737 )
• tamoxifen-treated mice have delayed gastric emptying

nervous system
abnormal synaptic transmission ( J:204737 )
• in tamoxifen treated mice, excitatory enteric neurotransmission is blocked as result of ICC depletion

muscle
abnormal intestinal peristalsis ( J:204737 )
• tamoxifen-treated mice show dysrhythmia resulting from uncoordinated spontaneous contractions and lack of slow-wave type electrical activity




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory