Phenotypes associated with this allele

• Allele Symbol: Ikbkg^tm1.1Dwat
• Allele Name: targeted mutation 1.1, Derek W Abbott
• Allele ID: MGI:5538732
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ikbkg^tm1.1Dwat/Ikbkg^+	B6.Cg-Ikbkg^tm1.1Dwat	MGI:5543237
cx2	Ikbkg^tm1.1Dwat/Ikbkg^tm1.1Dwat Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac	MGI:5543235
cx3	Ikbkg^tm1.1Dwat/Y Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac	MGI:5543236
ot4	Ikbkg^tm1.1Dwat/Y	B6.Cg-Ikbkg^tm1.1Dwat	MGI:5543238

Genotype
MGI:5543237

ht1

• Allelic Composition: Ikbkg^tm1.1Dwat/Ikbkg⁺
• Genetic Background: B6.Cg-Ikbkg^tm1.1Dwat

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal fertility/fecundity ( J:202106 )

♀ • difficult fecundancy with varying time between litters

immune system

enlarged spleen ( J:202106 )

♀ • greatly, due to an abundance of Gr1+CD11b+ cells

decreased B cell number ( J:202106 )

♀ • in the spleen

integument

hyperkeratosis ( J:202106 )

♀ • with elongated rete ridges

parakeratosis ( J:202106 )

♀ • with elongated rete ridges

spontaneous skin ulceration ( J:202106 )

♀

hematopoietic system

enlarged spleen ( J:202106 )

♀ • greatly, due to an abundance of Gr1+CD11b+ cells

decreased B cell number ( J:202106 )

♀ • in the spleen

growth/size/body

enlarged spleen ( J:202106 )

♀ • greatly, due to an abundance of Gr1+CD11b+ cells

Genotype
MGI:5543235

cx2

• Allelic Composition: Ikbkg^tm1.1Dwat/Ikbkg^tm1.1Dwat; Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

mortality/aging

premature death ( J:202106 )

♀

Genotype
MGI:5543236

cx3

• Allelic Composition: Ikbkg^tm1.1Dwat/Y; Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

mortality/aging

premature death ( J:202106 )

♂

preweaning lethality, incomplete penetrance ( J:202106 )

♂ • fewer than expected mice are generated

liver/biliary system

abnormal hepatocyte morphology ( J:202106 )

♂ • dysplasia with prominent nucleolar vacuoles

hepatic steatosis ( J:202106 )

♂ • macro- and microvesicular steatosis with centrilobular and zone 3 hepatitis

macrovesicular hepatic steatosis ( J:202106 )

microvesicular hepatic steatosis ( J:202106 )

liver fibrosis ( J:202106 )

♂ • moderate

abnormal liver physiology ( J:202106 )

♂ • liver disease

liver inflammation ( J:202106 )

♂ • in centrilobular and zone 3

abnormal liver regeneration ( J:202106 )

♂ • regenerative nodules

homeostasis/metabolism

increased circulating bilirubin level ( J:202106 )

♂

increased circulating alanine transaminase level ( J:202106 )

♂

increased circulating aspartate transaminase level ( J:202106 )

♂

increased circulating lactate dehydrogenase level ( J:202106 )

♂

immune system

immune system phenotype ( J:202106 )

♂N • mice do not exhibit skin lesions or spleen hypercellularity

liver inflammation ( J:202106 )

♂ • in centrilobular and zone 3

Genotype
MGI:5543238

ot4

• Allelic Composition: Ikbkg^tm1.1Dwat/Y
• Genetic Background: B6.Cg-Ikbkg^tm1.1Dwat

mortality/aging

preweaning lethality, complete penetrance ( J:202106 )

♂ • no mice are produced