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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tbx3tm3.1Moon
targeted mutation 3.1, Anne M Moon
MGI:5538564
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tbx3tm3.1Moon/Tbx3tm3.1Moon
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129 * C57BL/6 MGI:5538607
cn2
 		Tbx3tm3.1Moon/Tbx3tm3.1Moon
Tg(Mef2c-cre)2Blk/0 		involves: 129 * C57BL/6 MGI:5538608
cn3
 		Tbx3tm3.1Moon/Tbx3tm3.1Moon
Tg(GATA6-cre)#Jbeb/0 		involves: 129 * C57BL/6 MGI:5538606


Genotype
MGI:5538607
cn1
Allelic
Composition		 Tbx3tm3.1Moon/Tbx3tm3.1Moon
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx3tm3.1Moon mutation (0 available); any Tbx3 mutation (51 available)
Tg(CAG-cre/Esr1*)5Amc mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Atrioventricular block in tamoxifen treated Tbx3tm3.1Moon/Tbx3tm3.1Moon Tg(CAG-cre/Esr1*)5Amc/0 mice

cardiovascular system
abnormal sinus arrhythmia ( J:179977 )
• in tamoxifen-treated mice
atrioventricular block ( J:179977 )
• second degree in tamoxifen-treated mice




Genotype
MGI:5538608
cn2
Allelic
Composition		 Tbx3tm3.1Moon/Tbx3tm3.1Moon
Tg(Mef2c-cre)2Blk/0
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx3tm3.1Moon mutation (0 available); any Tbx3 mutation (51 available)
Tg(Mef2c-cre)2Blk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
irregular heartbeat ( J:179977 )
• atrial arrhythmia
atrioventricular block ( J:179977 )
• in most mice from E12.5 to E13.5




Genotype
MGI:5538606
cn3
Allelic
Composition		 Tbx3tm3.1Moon/Tbx3tm3.1Moon
Tg(GATA6-cre)#Jbeb/0
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx3tm3.1Moon mutation (0 available); any Tbx3 mutation (51 available)
Tg(GATA6-cre)#Jbeb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
atrioventricular block ( J:179977 )
• in most mice from E12.5 to E13.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory