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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Marcotm1Spt
targeted mutation 1, Shari Pilon-Thomas
MGI:5538543
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Marcotm1Spt/Marcotm1Spt C57BL/6-Marcotm1Spt MGI:5538544


Genotype
MGI:5538544
hm1
Allelic
Composition		 Marcotm1Spt/Marcotm1Spt
Genetic
Background		 C57BL/6-Marcotm1Spt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Marcotm1Spt mutation (0 available); any Marco mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal dendritic cell physiology ( J:204315 )
• injection of dendritic cells into C57BL/6 carrying B16 tumor cells results in prolonged survival and delayed tumor growth compared to when wild-type dendritic cells are injected
abnormal dendritic cell chemotaxis ( J:204315 )
• enhanced migratory ability when pulsed with tumor lysate
increased interferon-gamma secretion ( J:204315 )
• from dendritic cells pulsed with tumor lysate

cellular
abnormal dendritic cell chemotaxis ( J:204315 )
• enhanced migratory ability when pulsed with tumor lysate

hematopoietic system
abnormal dendritic cell chemotaxis ( J:204315 )
• enhanced migratory ability when pulsed with tumor lysate




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory