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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(ACTB-Edn1)721Clou
transgene insertion 721, David E Clouthier
MGI:5538246
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tg(ACTB-Edn1)721Clou/0
E2f1Tg(Wnt1-cre)2Sor/E2f1+ 		involves: 129S4/SvJae * C3H * C57BL/6 MGI:5754723
cn2
 		Myf5tm3(cre)Sor/Myf5+
Tg(ACTB-Edn1)721Clou/0 		involves: 129S4/SvJaeSor * C57BL/6 MGI:5754730


Genotype
MGI:5754723
cn1
Allelic
Composition		 Tg(ACTB-Edn1)721Clou/0
E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic
Background		 involves: 129S4/SvJae * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f1Tg(Wnt1-cre)2Sor mutation (2 available); any E2f1 mutation (25 available)
Tg(ACTB-Edn1)721Clou mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
basisphenoid bone hypoplasia ( J:221133 )
• basisphenoid bone is hypoplastic in the duplicated mandible
abnormal Meckel's cartilage morphology ( J:221133 )
• duplication of Meckel's cartilage in the duplicated mandible
abnormal temporal bone squamous part morphology ( J:221133 )
• the squamosal bone is deformed in the duplicated mandible
abnormal mandible morphology ( J:221133 )
• the duplicated mandible contains a duplicated Meckels cartilage, absent jugal and palatine bones, deformed squamosal bones, a hypoplastic basisphenoid bone and a palatal cleft
upper jaw to lower jaw transformation ( J:221133 )
• transformation of the maxilla into a mandible-like structure that is fused with the mandible
absent palatine bone ( J:221133 )
• palatine bone is absent in the duplicated mandible
absent zygomatic bone ( J:221133 )
• jugal bone is absent in the duplicated mandible
midline facial cleft ( J:221133 )
• mice exhibit a large mid-facial cleft

digestive/alimentary system

growth/size/body
cleft palate ( J:221133 )
midline facial cleft ( J:221133 )
• mice exhibit a large mid-facial cleft

skeleton
basisphenoid bone hypoplasia ( J:221133 )
• basisphenoid bone is hypoplastic in the duplicated mandible
abnormal Meckel's cartilage morphology ( J:221133 )
• duplication of Meckel's cartilage in the duplicated mandible
abnormal temporal bone squamous part morphology ( J:221133 )
• the squamosal bone is deformed in the duplicated mandible
abnormal mandible morphology ( J:221133 )
• the duplicated mandible contains a duplicated Meckels cartilage, absent jugal and palatine bones, deformed squamosal bones, a hypoplastic basisphenoid bone and a palatal cleft
upper jaw to lower jaw transformation ( J:221133 )
• transformation of the maxilla into a mandible-like structure that is fused with the mandible
absent palatine bone ( J:221133 )
• palatine bone is absent in the duplicated mandible
absent zygomatic bone ( J:221133 )
• jugal bone is absent in the duplicated mandible




Genotype
MGI:5754730
cn2
Allelic
Composition		 Myf5tm3(cre)Sor/Myf5+
Tg(ACTB-Edn1)721Clou/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm3(cre)Sor mutation (1 available); any Myf5 mutation (17 available)
Tg(ACTB-Edn1)721Clou mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal costal cartilage morphology ( J:221133 )
• fusions between the first and second costal cartilages




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory