Phenotypes associated with this allele

• Allele Symbol: Prkdc^m2Btlr
• Allele Name: mutation 2, Bruce Beutler
• Allele ID: MGI:5532715
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkdc^m2Btlr/Prkdc^m2Btlr	C57BL/6J-Prkdc^m2Btlr	MGI:5532739

Genotype
MGI:5532739

hm1

• Allelic Composition: Prkdc^m2Btlr/Prkdc^m2Btlr
• Genetic Background: C57BL/6J-Prkdc^m2Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell number ( J:204502 )

decreased CD4-positive, alpha-beta T cell number ( J:204502 )

decreased CD8-positive, alpha-beta T cell number ( J:204502 )

abnormal B cell physiology ( J:204502 )

• mice lack T-dependent IgG responses to both aluminum hydroxide (alum)-emulsified ovalbumin (OVA) and recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase and T-independent IgM response to NP-Ficoll

decreased IgG level ( J:204502 )

• in response to both aluminum hydroxide (alum)-emulsified ovalbumin (OVA) and recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase

decreased IgM level ( J:204502 )

• in response to NP-Ficoll

hematopoietic system

decreased B cell number ( J:204502 )

decreased CD4-positive, alpha-beta T cell number ( J:204502 )

decreased CD8-positive, alpha-beta T cell number ( J:204502 )

abnormal B cell physiology ( J:204502 )

• mice lack T-dependent IgG responses to both aluminum hydroxide (alum)-emulsified ovalbumin (OVA) and recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase and T-independent IgM response to NP-Ficoll

decreased IgG level ( J:204502 )

• in response to both aluminum hydroxide (alum)-emulsified ovalbumin (OVA) and recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase

decreased IgM level ( J:204502 )

• in response to NP-Ficoll