Phenotypes associated with this allele

• Allele Symbol: Tg(Penk-cre,-lacZ)1Mini
• Allele Name: transgene insertion 1, Liliana Minichiello
• Allele ID: MGI:5532538
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ntrk2^tm2Kln/Ntrk2^tm2Kln Tg(Penk-cre,-lacZ)1Mini/0	involves: 129S2/SvPas	MGI:5532658

Genotype
MGI:5532658

cn1

• Allelic Composition: Ntrk2^tm2Kln/Ntrk2^tm2Kln; Tg(Penk-cre,-lacZ)1Mini/0
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:204429 )

N • from 2-14 months of age, mutants and controls show similar motor coordination and motor function (no differences in hind-paw clasping or rotarod performance)

N • no differences in mutants and controls are detected with the inverted screen test

enhanced behavioral response to cocaine ( J:204429 )

• young adult (3 month-old) mutants show significant increases in distance traveled in open field tests when acutely challenged with cocaine, compared to wild-type mice

abnormal gait ( J:204429 )

• mutants display subtle gait differences compared to controls at 5 months, including a smaller print width for the left hind paw and differences in footfalls of 2 different paws and slight altered timely coordination between ipsilateral (right fore- and hind-) paws and girdle (right and left) hindpaws

increased locomotor activity ( J:204429 )

• by 9 months of age and after, mutants show significantly higher locomotion in open field tests compared to wild-type

induced hyperactivity ( J:204429 )

• observed when acutely challenged with cocaine at 3 months of age

nervous system

nervous system phenotype ( J:204429 )

N • no loss of medium-sized spiny neurons (MSNs) in the striatum is detected compared to wild-type littermates; striatal volume in normal at 12 months of age

N • corticostriatal synaptic properties and striatopallidal projections are intact in mutants