Phenotypes associated with this allele

• Allele Symbol: Hsd11b1^tm1.2Tuck
• Allele Name: targeted mutation 1.2, David Tucker
• Allele ID: MGI:5532495
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hsd11b1^tm1.2Tuck/Hsd11b1^tm1.2Tuck	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5544480

Genotype
MGI:5544480

hm1

• Allelic Composition: Hsd11b1^tm1.2Tuck/Hsd11b1^tm1.2Tuck
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:203302 )

N • mice exhibit normal metabolic and HPA axis phenotype

abnormal circulating insulin level ( J:203302 )

• mice are protected from 11-DHC-induced hyperinsulinemia compared with control mice

growth/size/body

decreased susceptibility to weight gain ( J:203302 )

• mice treated with 11-DHC do not exhibit weight gain unlike control mice

adipose tissue

abnormal epididymal fat pad morphology ( J:203302 )

• no epididymal fat pad mass change in mice treated with 11-DHC