Phenotypes associated with this allele

• Allele Symbol: Chp1^vac
• Allele Name: vacillator
• Allele ID: MGI:5529475
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chp1^vac/Chp1^vac	B6(C3Fe)-Chp1^vac	MGI:5529477

Genotype
MGI:5529477

hm1

• Allelic Composition: Chp1^vac/Chp1^vac
• Genetic Background: B6(C3Fe)-Chp1^vac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

tremors ( J:199873 )

• develop mild tremors by 4-5 weeks of age

ataxia ( J:199873 )

• pronounced ataxic gait by 7 weeks of age

nervous system

Purkinje cell degeneration ( J:199873 )

• develop extensive axonal dystrophy of cerebellar Purkinje cells at 4-5 weeks of age, with signs of degeneration detected by P15

• widespread hypertrophy of Purkinje cell axons at 5 weeks of age and these axons display many abnormal focal swellings forming varicosities or large spheroids, characteristic hallmarks of degenerating axons

• extensive loss of Purkinje cells is seen at 4 months of age but not at 7 weeks of age

• loss is progressive with many cells degenerated, particularly in the rostral region in 10 month old mice

abnormal Purkinje cell axon morphology ( J:199873 )

• Purkinje cell axon collaterals form misshapen boutons that are often displaced

abnormal synaptic bouton morphology ( J:199873 )

• Purkinje cell axon collaterals form misshapen boutons that are often displaced

axon degeneration ( J:199873 )

• widespread hypertrophy of Purkinje cell axons at 5 weeks of age and these axons display many abnormal focal swellings forming varicosities or large spheroids, characteristic hallmarks of degenerating axons

• signs of Purkinje cell axon degeneration are detected by P15

axonal dystrophy ( J:199873 )

• develop extensive axonal dystrophy of cerebellar Purkinje cells at 4-5 weeks of age