All Phenotypes Mecp2<tm2.1Meg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mecp2^tm2.1Meg
targeted mutation 2.1, Michael E Greenberg
MGI:5529372

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Mecp2^tm2.1Meg/Y	involves: 129P2/OlaHsd	MGI:5529468

Allelic Composition	Mecp2^tm2.1Meg/Y
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm2.1Meg mutation (1 available); any Mecp2 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:203745 )

• 12 of 27 mice die by 18.5 weeks

behavior/neurological

abnormal behavior ( J:203745 )

• authors state that mice develop a severe phenotype resembling that of Mecp2^tm1.1Bird

limb grasping ( J:203745 )

• at 6 weeks

impaired coordination ( J:203745 )

• on a rotarod at 15 to 18 weeks

decreased locomotor activity ( J:203745 )

• reduced distance traveled in an open field at 15 to 18 weeks

nervous system

decreased brain weight ( J:203745 )

• at 15 to 18 weeks

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:203745

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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