All Phenotypes Mecp2<tm5.1Bird> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mecp2^tm5.1Bird
targeted mutation 5.1, Adrian Bird
MGI:5529365

Summary

2 genotypes

Allelic Composition	Mecp2^tm5.1Bird/Mecp2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm5.1Bird mutation (1 available); any Mecp2 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:227401 )

• females exhibit milder motor coordination and behavioral phenotypes than males

Allelic Composition	Mecp2^tm5.1Bird/Y
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm5.1Bird mutation (1 available); any Mecp2 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:227401 )

• motor coordination and behavioral phenotypes are intermediate to phenotypes observed in mice carrying Mecp^tm4.1Brd and Mecp^tm6.1Brd

• onset of phenotypes is initially rapid and then stable until 33 weeks as compared to mice carrying Mecp^tm4.1Brd and Mecp^tm6.1Brd

• increased time in open arms of elevated plus maze as compared to controls

• increase in latency to fall in hanging wire test as compared to controls

growth/size/body

decreased body weight ( J:227401 )

mortality/aging

premature death ( J:227401 )

• median survival is 30 weeks

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:227401

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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