All Phenotypes Mecp2<tm4.1Bird> MGI Mouse

Phenotypes associated with this allele

Allelic Composition	Mecp2^tm4.1Bird/Mecp2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm4.1Bird mutation (1 available); any Mecp2 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:227401 )

• females exhibit milder motor coordination and behavioral phenotypes than males

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:227401 )

• motor coordination and behavioral phenotypes are more severe than in mice carrying Mecp^tm5.1Brd and Mecp^tm6.1Brd

• onset of phenotypes is more rapid than observed in mice carrying Mecp^tm5.1Brd and Mecp^tm6.1Brd

abnormal motor learning ( J:227401 )

• decrease in latency to fall in 3-day accelerated rotarod-learning paradigm by day 3 as compared to controls

• increased time in open arms of elevated plus maze as compared to controls

• increase in latency to fall in hanging wire test as compared to wild-type litter mates, but not as compared to Mecp^tm3.1Brd (WT-GFP) control

growth/size/body

decreased body weight ( J:227401 )

mortality/aging

premature death ( J:227401 )

• median survival 13 week

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:227401

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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