Phenotypes associated with this allele

• Allele Symbol: Ampd3^tm1Tm
• Allele Name: targeted mutation 1, Takayuki Morisak
• Allele ID: MGI:5529271
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ampd3^tm1Tm/Ampd3^tm1Tm	Not Specified	MGI:5529919
cx2	Ampd3^tm1Tm/Ampd3^tm1Tm Pklr^slc/Pklr^slc	involves: CBA/NSlc	MGI:5529923

Genotype
MGI:5529919

hm1

• Allelic Composition: Ampd3^tm1Tm/Ampd3^tm1Tm
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased mean corpuscular volume ( J:203909 )

• slight but significant increase

abnormal erythrocyte physiology ( J:203909 )

• ATP, ADP, and AMP levels increase in RBC

• ATP, ADP, and AMP levels drop with fasting but remain higher than for controls

• GTP levels decrease

increased erythrocyte osmotic fragility ( J:203909 )

• RBC are more fragile under low osmotic conditions

• RBC fragility is unaffected by fasting

immune system

lung inflammation ( J:201211 )

• greatly increased inflammation relative to controls in lungs after hind-limb ischemia and reperfusion

respiratory system

lung inflammation ( J:201211 )

• greatly increased inflammation relative to controls in lungs after hind-limb ischemia and reperfusion

Genotype
MGI:5529923

cx2

• Allelic Composition: Ampd3^tm1Tm/Ampd3^tm1Tm; Pklr^slc/Pklr^slc
• Genetic Background: involves: CBA/NSlc

growth/size/body

enlarged spleen ( J:203909 )

hematopoietic system

enlarged spleen ( J:203909 )

anemia ( J:203909 )

abnormal erythrocyte morphology ( J:203909 )

reticulocytosis ( J:203909 )

abnormal erythrocyte physiology ( J:203909 )

• ATP, ADP, and AMP levels increase in RBC

increased erythrocyte osmotic fragility ( J:203909 )

• RBC are more fragile under low osmotic conditions

immune system

enlarged spleen ( J:203909 )