All Phenotypes Itgb1<tm15.1Ref> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Itgb1^tm15.1Ref
targeted mutation 15.1, Reinhard Fassler
MGI:5529154

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itgb1^tm15.1Ref/Itgb1^tm15.1Ref	Not Specified	MGI:5529162
ht2	Itgb1^tm14.1Ref/Itgb1^tm15.1Ref	Not Specified	MGI:5529165
cn3	Itgb1^tm1Ref/Itgb1^tm15.1Ref Tg(KRT5-cre)5132Jlj/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J	MGI:5529163

Allelic Composition	Itgb1^tm15.1Ref/Itgb1^tm15.1Ref
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1^tm15.1Ref mutation (0 available); any Itgb1 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:203018 )

• peri-implantation lethality indicated by severe malformations at E7.5

cellular

abnormal cell physiology ( J:203018 )

• ES cells adhere less to feeder cells compared with wild-type cells

Allelic Composition	Itgb1^tm14.1Ref/Itgb1^tm15.1Ref
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1^tm14.1Ref mutation (0 available); any Itgb1 mutation (59 available)
Itgb1^tm15.1Ref mutation (0 available); any Itgb1 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:203018 )

• peri-implantation lethality indicated by severe malformations at E7.5

cellular

abnormal cell physiology ( J:203018 )

• ES cells adhere less to feeder cells compared with wild-type cells

Allelic Composition	Itgb1^tm1Ref/Itgb1^tm15.1Ref Tg(KRT5-cre)5132Jlj/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1^tm15.1Ref mutation (0 available); any Itgb1 mutation (59 available)
Itgb1^tm1Ref mutation (0 available); any Itgb1 mutation (59 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

decreased keratinocyte adhesion ( J:203018 )

• defective adhesion and more pronounced spreading

decreased keratinocyte proliferation ( J:203018 )

• cells do not grow into a confluent monolayer and undergo rapidly initiated terminal differentiation

abnormal hair growth ( J:203018 )

• patchy hair loss over the dorsal midline of the skull

enlarged hair follicles ( J:203018 )

• intermixed with normal follicles

abnormal epidermal layer morphology ( J:203018 )

• less affected than in Itgb1^tm1Ref/Itgb1^tm1Ref Tg(KRT1-5-cre)5132Jlj mice

• however, no subepidermal blistering is observed

cellular

decreased keratinocyte adhesion ( J:203018 )

• defective adhesion and more pronounced spreading

decreased keratinocyte proliferation ( J:203018 )

• cells do not grow into a confluent monolayer and undergo rapidly initiated terminal differentiation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23