Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1tm14.1Ref mutation
(0 available);
any
Itgb1 mutation
(59 available)
|
|
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mortality/aging
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• no offspring are produced from breeding heterozygotes
|
|
• peri-implantation lethality indicated by severe malformations at E7.5
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cellular
|
• ES cells adhere less to feeder cells compared with wild-type cells
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1tm14.1Ref mutation
(0 available);
any
Itgb1 mutation
(59 available)
Itgb1tm15.1Ref mutation
(0 available);
any
Itgb1 mutation
(59 available)
|
|
|
mortality/aging
|
• peri-implantation lethality indicated by severe malformations at E7.5
|
cellular
|
• ES cells adhere less to feeder cells compared with wild-type cells
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1tm14.1Ref mutation
(0 available);
any
Itgb1 mutation
(59 available)
Itgb1tm1Ref mutation
(0 available);
any
Itgb1 mutation
(59 available)
Tg(KRT5-cre)5132Jlj mutation
(1 available)
|
|
|
integument
N |
• mice exhibit normal follicle morphogenesis and keratinocyte spreading and proliferation
|
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• patchy hair loss over the dorsal midline of the skull
|
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• less affected than in Itgb1tm1Ref/Itgb1tm1Ref Tg(KRT1-5-cre)5132Jlj mice
• however, no subepidermal blistering is observed
|
homeostasis/metabolism
cellular