Phenotypes associated with this allele

• Allele Symbol: Atoh7^{tm1.1(Ascl1)Nlbr}
• Allele Name: targeted mutation 1.1, Nadean L Brown
• Allele ID: MGI:5529126
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atoh7^tm1.1(Ascl1)Nlbr/Atoh7^tm1.1(Ascl1)Nlbr	either: 129(Cg)-Atoh7^tm1.1(Ascl1)Nlbr or B6.129S6(Cg)-Atoh7^tm1.1(Ascl1)Nlbr or (involves: 129S6/SvEvTac * C57BL/6J * CD-1 * FVB/N)	MGI:5529142
cn2	Atoh7^tm1.1(Ascl1)Nlbr/Atoh7^tm1.1(Ascl1)Nlbr Tg(Atoh7-cre)360Gla/0 Tg(CAG-Bgeo/GFP)21Lbe/0	either: (involves: 129 * C57BL/6 * FVB/N * SJL) or (involves: 129 * C57BL/6 * CD-1 * FVB/N * SJL)	MGI:5529143
cn3	Atoh7^tm1.1(Ascl1)Nlbr/Atoh7^+ Tg(Atoh7-cre)360Gla/0 Tg(CAG-Bgeo/GFP)21Lbe/0	either: (involves: 129 * C57BL/6 * FVB/N * SJL) or (involves: 129 * C57BL/6 * CD-1 * FVB/N * SJL)	MGI:5529144

Genotype
MGI:5529142

hm1

• Allelic Composition: Atoh7^{tm1.1(Ascl1)Nlbr}/Atoh7^{tm1.1(Ascl1)Nlbr}
• Genetic Background: either: 129(Cg)-Atoh7^{tm1.1(Ascl1)Nlbr} or B6.129S6(Cg)-Atoh7^{tm1.1(Ascl1)Nlbr} or (involves: 129S6/SvEvTac * C57BL/6J * CD-1 * FVB/N)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina vasculature morphology ( J:203642 )

• ectopic

abnormal Muller cell morphology ( J:203642 )

• reduced

decreased retina ganglion cell number ( J:203642 )

increased retina cone cell number ( J:203642 )

abnormal retina bipolar cell morphology ( J:203642 )

• reduced

absent optic nerve ( J:203642 )

• without the loss of cranial nerves that innervate extraocular muscles

decreased total retina thickness ( J:203642 )

nervous system

abnormal Muller cell morphology ( J:203642 )

• reduced

decreased retina ganglion cell number ( J:203642 )

increased retina cone cell number ( J:203642 )

abnormal retina bipolar cell morphology ( J:203642 )

• reduced

absent optic nerve ( J:203642 )

• without the loss of cranial nerves that innervate extraocular muscles

cardiovascular system

abnormal retina vasculature morphology ( J:203642 )

• ectopic

Genotype
MGI:5529143

cn2

• Allelic Composition: Atoh7^{tm1.1(Ascl1)Nlbr}/Atoh7^{tm1.1(Ascl1)Nlbr}; Tg(Atoh7-cre)360Gla/0; Tg(CAG-Bgeo/GFP)21Lbe/0
• Genetic Background: either: (involves: 129 * C57BL/6 * FVB/N * SJL) or (involves: 129 * C57BL/6 * CD-1 * FVB/N * SJL)

vision/eye

increased retina apoptosis ( J:203642 )

• increased retinal apoptosis at E12.5 to E16.5

decreased retina ganglion cell number ( J:203642 )

• cell autonomous phenotype

increased retina cone cell number ( J:203642 )

• cell nonautonomous phenotype

abnormal retina progenitor cell morphology ( J:203642 )

• at E12.5 and E13.5, retinal progenitor cells exhibit a block to cell cycle progression and retinal ganglion cell differentiation

nervous system

decreased retina ganglion cell number ( J:203642 )

• cell autonomous phenotype

increased retina cone cell number ( J:203642 )

• cell nonautonomous phenotype

cellular

abnormal cell cycle ( J:203642 )

• at E12.5 and E13.5, retinal progenitor cells exhibit a block to cell cycle progression

increased retina apoptosis ( J:203642 )

• increased retinal apoptosis at E12.5 to E16.5

Genotype
MGI:5529144

cn3

• Allelic Composition: Atoh7^{tm1.1(Ascl1)Nlbr}/Atoh7⁺; Tg(Atoh7-cre)360Gla/0; Tg(CAG-Bgeo/GFP)21Lbe/0
• Genetic Background: either: (involves: 129 * C57BL/6 * FVB/N * SJL) or (involves: 129 * C57BL/6 * CD-1 * FVB/N * SJL)

vision/eye

decreased retina rod cell number ( J:203642 )

• small autonomous loss

abnormal retina development ( J:203642 )

• delayed retinal ganglion cell differentiation

• however, adult mice exhibit normal proportion of retinal ganglion cells

nervous system

decreased retina rod cell number ( J:203642 )

• small autonomous loss