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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Col1a1tm1(tetO-Irf4)Sing
targeted mutation 1, Harinder Singh
MGI:5529080
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Col1a1tm1(tetO-Irf4)Sing/Col1a1tm1(tetO-Irf4)Sing
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Irf4tm1Mak/Irf4+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:5529093
cx2
Col1a1tm1(tetO-Irf4)Sing/Col1a1tm1(tetO-Irf4)Sing
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Irf4tm1Mak/Irf4tm1Mak
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:5529094


Genotype
MGI:5529093
cx1
Allelic
Composition
Col1a1tm1(tetO-Irf4)Sing/Col1a1tm1(tetO-Irf4)Sing
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Irf4tm1Mak/Irf4+
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm1(tetO-Irf4)Sing mutation (0 available); any Col1a1 mutation (160 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (30 available); any Gt(ROSA)26Sor mutation (944 available)
Irf4tm1Mak mutation (2 available); any Irf4 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• doxycycline-treated mice exhibit enhanced plasma cell generation at the expense of class switch recombination
• doxycycline-treated mice exhibit enhanced plasma cell generation at the expense of class switch recombination

immune system
• doxycycline-treated mice exhibit enhanced plasma cell generation at the expense of class switch recombination
• doxycycline-treated mice exhibit enhanced plasma cell generation at the expense of class switch recombination




Genotype
MGI:5529094
cx2
Allelic
Composition
Col1a1tm1(tetO-Irf4)Sing/Col1a1tm1(tetO-Irf4)Sing
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Irf4tm1Mak/Irf4tm1Mak
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm1(tetO-Irf4)Sing mutation (0 available); any Col1a1 mutation (160 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (30 available); any Gt(ROSA)26Sor mutation (944 available)
Irf4tm1Mak mutation (2 available); any Irf4 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• doxycycline-treated mice exhibit enhanced plasma cell generation at the expense of class switch recombination but not as severe as in mice heterozygous for Irf4tm1Mak
• doxycycline-treated mice exhibit enhanced plasma cell generation at the expense of class switch recombination but not as severe as in mice heterozygous for Irf4tm1Mak

immune system
• doxycycline-treated mice exhibit enhanced plasma cell generation at the expense of class switch recombination but not as severe as in mice heterozygous for Irf4tm1Mak
• doxycycline-treated mice exhibit enhanced plasma cell generation at the expense of class switch recombination but not as severe as in mice heterozygous for Irf4tm1Mak





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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory