Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Ito mutation
(1 available);
any
Emx1 mutation
(34 available)
Mpp3tm1.1Wij mutation
(0 available);
any
Mpp3 mutation
(44 available)
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nervous system
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• adverse affect on neuron migration
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• mild cellular disorganization in the ventricular zone of the cortex at E12.5
• becoming more extreme at E16.5
• normal cellular organization at the level of the 3rd ventricle where cre is not expressed
• cortex thickness and lamination are normal at E16.5
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cellular
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• spindle orientation in cortical progenitor cells tends to shift from horizontal to oblique
• vertical spindle orientation is normal
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• increased number of mitotic cells in cortex with basal location rather than apical location
• apically located proliferating cells are also increased
• increased number of mitotic cells in cortex over all
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• adverse affect on neuron migration
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpp3tm1.1Wij mutation
(0 available);
any
Mpp3 mutation
(44 available)
Tg(rx3-icre)1Mjam mutation
(0 available)
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vision/eye
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• no histological abnormalities at 2 months of age
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• occasional ingression of photoreceptors at 2 months
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• defects observed at 6 months along with vascular abnormalities
• occasional ectopic photo receptors between the outer limiting membrane and the retinal pigment epithelium
• thinning of outer limiting membrane and integrity disrupted at 6 and 12 months
• 6 month old mice exposed to 3000 lux white light for 72 hours develop foci of cells in the space between the outer limiting membrane and the retinal pigment layer
• integrity of outer limiting membrane is disrupted in 6 month old mice by exposure to 3000 lux white light for 72 hours
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• occasional retinal degeneration and rosettes at 3 months of age
• degeneration detected at 6 months of age
• morphological defects are more distinct at 12 months
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• increased in 6 month old mice exposed to 3000 lux white light for 72 hours
• massive gliosis when exposed to light
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• both scotopic and photopic retinography varies from normal to mildly subnormal depending on the extent of morphological abnormalities
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpp3tm1.1Wij mutation
(0 available);
any
Mpp3 mutation
(44 available)
Tg(Chx10-EGFP/cre,-ALPP)2Clc mutation
(1 available)
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vision/eye
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• phenotype similar to that when Tg(rx3-icre)1Mjam was used for cre expression
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• sporadic loss of photoreceptors at 18 months
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• areas of disruption and ectopic photoreceptors at 18 months
• slight thinning of layer at 6, 12, 18 months
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• phenotype similar to that when Tg(rx3-icre)1Mjam was used for cre expression
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpp3tm1.1Wij mutation
(0 available);
any
Mpp3 mutation
(44 available)
Tg(Chx10-EGFP/cre,-ALPP)2Clc mutation
(1 available)
Tg(RNU6-RNAi:Mpp5)13Wij mutation
(0 available)
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vision/eye
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• four fold increase in degenerative spots on retinas compared to controls
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Analysis Tools