All Phenotypes Ank1<M1Btlr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ank1^M1Btlr
mutation 1, Bruce Beutler
MGI:5528853

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ank1^M1Btlr/Ank1^M1Btlr	C57BL/6J-Ank1^m1Btlr	MGI:5528857
ht2	Ank1^M1Btlr/Ank1⁺	C57BL/6J-Ank1^m1Btlr	MGI:5528856

Allelic Composition	Ank1^M1Btlr/Ank1^M1Btlr
Genetic Background	C57BL/6J-Ank1^m1Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ank1^M1Btlr mutation (1 available); any Ank1 mutation (106 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

enlarged spleen ( J:203831 )

• slightly

hematopoietic system

extramedullary hematopoiesis ( J:203831 )

• in the spleen

abnormal erythrocyte morphology ( J:203831 )

• membrane blebs

increased erythrocyte cell number ( J:203831 )

decreased mean corpuscular hemoglobin ( J:203831 )

decreased mean corpuscular volume ( J:203831 )

microcytosis ( J:203831 )

spherocytosis ( J:203831 )

stomatocytosis ( J:203831 )

reticulocytosis ( J:203831 )

• mild

abnormal spleen morphology ( J:203831 )

• effacement of normal spleen architecture

enlarged spleen ( J:203831 )

• slightly

increased spleen iron level ( J:203831 )

hemolysis ( J:203831 )

• erythrocyte half-life is 18 days compared with 28 in wild-type mice

increased erythrocyte osmotic fragility ( J:203831 )

• increased osmotic fragility

homeostasis/metabolism

increased spleen iron level ( J:203831 )

increased circulating bilirubin level ( J:203831 )

increased circulating erythropoietin level ( J:203831 )

• at 8 weeks

immune system

abnormal spleen morphology ( J:203831 )

• effacement of normal spleen architecture

enlarged spleen ( J:203831 )

• slightly

increased spleen iron level ( J:203831 )

Allelic Composition	Ank1^M1Btlr/Ank1⁺
Genetic Background	C57BL/6J-Ank1^m1Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ank1^M1Btlr mutation (1 available); any Ank1 mutation (106 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased erythrocyte cell number ( J:203831 )

decreased mean corpuscular hemoglobin ( J:203831 )

decreased mean corpuscular volume ( J:203831 )

hemolysis ( J:203831 )

increased erythrocyte osmotic fragility ( J:203831 )

• increased osmotic fragility

homeostasis/metabolism

increased circulating bilirubin level ( J:203831 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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