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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lckm2Btlr
mutation 2, Bruce Beutler
MGI:5528710
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lckm2Btlr/Lckm2Btlr C57BL/6J-Lckm2Btlr MGI:5528718


Genotype
MGI:5528718
hm1
Allelic
Composition		 Lckm2Btlr/Lckm2Btlr
Genetic
Background		 C57BL/6J-Lckm2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lckm2Btlr mutation (0 available); any Lck mutation (93 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgG level ( J:203759 )
• mice exhibit a lack of T-dependent IgG responses to both aluminum hydroxide (alum)-emulsified ovalbumin (OVA) and recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase compared with wild-type mice

hematopoietic system
decreased IgG level ( J:203759 )
• mice exhibit a lack of T-dependent IgG responses to both aluminum hydroxide (alum)-emulsified ovalbumin (OVA) and recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase compared with wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory