Phenotypes associated with this allele

• Allele Symbol: Lpar5^tm1Zcv
• Allele Name: targeted mutation 1, Zsuzsanna Callaerts-Vegh
• Allele ID: MGI:5527440
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lpar5^tm1Zcv/Lpar5^tm1Zcv	involves: 129 * 129S9/SvEvH	MGI:5527449

Genotype
MGI:5527449

hm1

• Allelic Composition: Lpar5^tm1Zcv/Lpar5^tm1Zcv
• Genetic Background: involves: 129 * 129S9/SvEvH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:203330 )

N • mice exhibit normal passive avoidance learning and fear conditioning

abnormal associative learning ( J:203330 )

• in a scheduled appetitive conditioning test, mice exhibit higher response rate and increased responding with fixed ratio, variable ratio and variable interval schedules during continuous reinforcement compared with wild-type mice

enhanced spatial learning ( J:203330 )

• in a Morris water maze, mice exhibit increased spatial based strategies during acquisition and more efficient navigation during reversal training compared with wild-type mice

decreased anxiety-related response ( J:203330 )

• in an open field

• in an elevated plus maze

• mice exhibit less freezing during baseline exposure to the training cage prior to fear conditioning compared with wild-type mice

• however, mice exhibit normal defensive marble burying behavior

enhanced coordination ( J:203330 )

• on an accelerating rotarod

hyperactivity ( J:203330 )

• in the dark phase in a cage

• in an open field

increased vertical activity ( J:203330 )

abnormal nociception after inflammation ( J:203330 )

• at 24 h, CFA-treated mice exhibit baseline thermal sensitivity unlike wild-type mice that continue to exhibit thermal hyperalgesia

abnormal pain threshold ( J:203330 )

• after nerve injury and acetone challenge, mice develop less cold allodynia compared with wild-type mice

increased thermal nociceptive threshold ( J:203330 )

• in a tail withdrawal test

abnormal social investigation ( J:203330 )

• decreased social exploration