Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc12a3tm1Ges mutation
(1 available);
any
Slc12a3 mutation
(54 available)
Tg(Wnk4*Q562E)#Rpl mutation
(0 available)
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cardiovascular system
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N |
• on both normal and high-potassium diets, mice show reduced blood pressure levels compared to single Tg(Wnk4*Q562E)#Rpl homozygotes
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homeostasis/metabolism
renal/urinary system
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N |
• on both normal and high-potassium diets, mice show elimination of distal convoluted tube hyperplasia
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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cardiovascular system
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N |
• a high-salt (8%) diet increases blood pressure in mutants to a similar amount as in wild-type mice
• a low-salt diet (0.1%) reduces blood pressure in mutants to a similar amount as in wild-type mice
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• diastolic blood pressure is increased in 3-4 month old unanesthetized and unrestrained mutants
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• systolic blood pressure is increased in 3-4 month old unanesthetized and unrestrained mutants
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homeostasis/metabolism
mortality/aging
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• on a 10% potassium diet that is well tolerated by wild-type mice, mutants begin dying within several days
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renal/urinary system
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• a 50% increase in urinary calcium
• the increase in urinary calcium is exacerbated on a high-salt diet, with mutants showing a 6-fold increase compared to a 2-fold increase in wild-type mice
• treatment with hydrochlorothiazide, a specific Slc12a3 inhibitor, corrects hypercalciuria
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• increase in apical surface area of distal convoluted tube epithelium
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• despite hyperkalemia, mutants show no increase in urinary potassium excretion, indicating impaired renal electrolyte handling
• on a 5% potassium diet, mutants survive, however they show an increase in serum potassium, but not urinary potassium levels, indicating a urinary secretory defect
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Analysis Tools