Phenotypes associated with this allele

• Allele Symbol: Tg(Wnk4)#Rpl
• Allele Name: transgene insertion, Richard P Lifton
• Allele ID: MGI:5525134
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Wnk4)#Rpl/Tg(Wnk4)#Rpl	involves: C3H * C57BL/6	MGI:5525136

Genotype
MGI:5525136

tg1

• Allelic Composition: Tg(Wnk4)#Rpl/Tg(Wnk4)#Rpl
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:113094 )

N • a low-salt diet (0.1%) reduces blood pressure in mutants to a similar amount as in wild-type mice

N • a high-salt (8%) diet increases blood pressure in mutants to a similar amount as in wild-type mice

decreased systemic arterial diastolic blood pressure ( J:113094 )

• diastolic blood pressure is decreased in 3-4 month old unanesthetized and unrestrained mutants

decreased systemic arterial systolic blood pressure ( J:113094 )

• systolic blood pressure is decreased in 3-4 month old unanesthetized and unrestrained mutants

homeostasis/metabolism

decreased circulating magnesium level ( J:113094 )

• serum magnesium levels are slightly reduced

decreased circulating potassium level ( J:113094 )

• on a low potassium diet, mutants develop reduced potassium levels compared to wild-type mice

decreased circulating chloride level ( J:113094 )

• serum chloride levels are modestly reduced

• however, serum potassium and bicarbonate levels are normal

decreased urine calcium level ( J:113094 )

• a 25% reduction in urinary calcium

renal/urinary system

decreased urine calcium level ( J:113094 )

• a 25% reduction in urinary calcium

abnormal distal convoluted tubule morphology ( J:113094 )

• decrease in apical surface area of distal convoluted tube epithelium