Phenotypes associated with this allele

• Allele Symbol: Ccdc88b^m1Pgrs
• Allele Name: mutation 1, Philippe Gros
• Allele ID: MGI:5523920
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccdc88b^m1Pgrs/Ccdc88b^m1Pgrs	involves: 129S1/SvImJ * C57BL/6J * C57BL/10J	MGI:5765999
hm2	Ccdc88b^m1Pgrs/Ccdc88b^m1Pgrs	involves: C57BL/6J * C57BL/10J	MGI:5765997

Genotype
MGI:5765999

hm1

• Allelic Composition: Ccdc88b^m1Pgrs/Ccdc88b^m1Pgrs
• Genetic Background: involves: 129S1/SvImJ * C57BL/6J * C57BL/10J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:230618 )

• in Plasmodium berghei-infected mice

immune system

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:230618 )

• in Plasmodium berghei-infected mice

Genotype
MGI:5765997

hm2

• Allelic Composition: Ccdc88b^m1Pgrs/Ccdc88b^m1Pgrs
• Genetic Background: involves: C57BL/6J * C57BL/10J

mortality/aging

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:230618 )

• in Plasmodium berghei-infected mice

immune system

immune system phenotype ( J:230618 )

N • mice exhibit normal CD4+ T cell compartment

decreased T cell proliferation ( J:230618 )

• in response to anti-CD3 and anti-CD28 stimulation in CD8+ and CD4+ T cells

• however, response to PMA/Iono stimulation is normal

decreased CD8-positive, alpha-beta T cell number ( J:230618 )

• decreased total number and proportion (9-fold) of CD44^hi CD8+ T cells

• decreased splenic peripheral circulating CD8+ T cells

decreased interferon-gamma secretion ( J:230618 )

• in CD8+ T cells after activation with anti-CD3 and anti-CD28 or treatment with PMA/Iono

• in CD8+ and CD4+ T cells from P. berghei-infected mice after stimulation with CD3/CD28 or PMA/Iono

decreased tumor necrosis factor secretion ( J:230618 )

• in CD8+ and CD4+ T cells after activation with anti-CD3 and anti-CD28 or treatment with PMA/Iono

• in CD8+ and CD4+ T cells from P. berghei-infected mice after stimulation with CD3/CD28 or PMA/Iono

decreased susceptibility to parasitic infection ( J:230618 )

• Plasmodium berghei-infected mice fail to develop cerebral symptoms and exhibit improved survival compared with wild-type mice

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:230618 )

• in Plasmodium berghei-infected mice

hematopoietic system

decreased T cell proliferation ( J:230618 )

• in response to anti-CD3 and anti-CD28 stimulation in CD8+ and CD4+ T cells

• however, response to PMA/Iono stimulation is normal

decreased CD8-positive, alpha-beta T cell number ( J:230618 )

• decreased total number and proportion (9-fold) of CD44^hi CD8+ T cells

• decreased splenic peripheral circulating CD8+ T cells

increased myeloid cell number ( J:230618 )

• in the spleen of P. berghei-infected mice

cellular

decreased T cell proliferation ( J:230618 )

• in response to anti-CD3 and anti-CD28 stimulation in CD8+ and CD4+ T cells

• however, response to PMA/Iono stimulation is normal