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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mir200btm1.1Osb
targeted mutation 1.1, Research Institute for Microbial Diseases, Osaka University
MGI:5523790
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Mir200btm1.1Osb/Mir200btm1.1Osb
Mir429m1Osb/Mir429m1Osb
involves: 129S2/SvPas * C57BL/6 MGI:5523867


Genotype
MGI:5523867
cx1
Allelic
Composition
Mir200btm1.1Osb/Mir200btm1.1Osb
Mir429m1Osb/Mir429m1Osb
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir200btm1.1Osb mutation (2 available); any Mir200b mutation (4 available)
Mir429m1Osb mutation (1 available); any Mir429 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• male mice exhibit normal fertility, testis and progesterol serum levels
• in female mice
• however, superovulated mice produce normal numbers of oocytes
• in female mice
• however, superovulated mice produce normal corpora lutea
• in female mice
• in female mice
• however, cyclicity is maintained
• female mice produce smaller litters than expected
• female mice that become pregnant do not become pregnant again
• however, fecundity is rescued by transgenic expression of knocked-out microRNAs and in vitro fertilized superovulated oocytes exhibit normal fertilization
• from female mice

homeostasis/metabolism
• in female mice
• however, levels are normal in male mice
• in the pituitary of female mice luteinizing hormone level
• ovariectomized female mice exhibit reduced basal and estradiol-induced compared with wild-type mice

endocrine/exocrine glands
• in female mice
• however, superovulated mice produce normal corpora lutea

cellular
• in female mice
• however, superovulated mice produce normal numbers of oocytes





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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory