Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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reproductive system
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• no gross uterine abnormalities are detected
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• occasional minor coiling near the epididymal junction
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• show evidence of subfertility
• pups in litters born to homozygous females often die postnatally with no milk spot or are severely runted
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• seen when mutant females when mated to wild-type males
• pups in litters born to homozygous females often die postnatally with no milk spot or are severely runted
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• males fail to produce vaginal plugs when mated with wild-type females
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behavior/neurological
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• males fail to produce vaginal plugs when mated with wild-type females
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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reproductive system
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• anteriorization of the uterus is exacerbated compared to mice homozygous for the Hoxa mutation alone
• coiled for nearly half the length
• uteri closely resemble oviducts
• reduction of the stromal layer and an increase in luminal branching
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• smaller tubules which resemble those in the more anterior caput
• smaller with an extremely thin muscle layer, thinning is more severe than in mice homozygous for the Hoxa mutation alone
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• smaller caudal epididymis
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• significant enhancement of the anteriorization compared to mice homozygous for the Hoxa mutation alone
• extreme coiling from the epididymal junction extending posterior for approximately one-third of the length
• resembles the wild-type caudal epididymis with thinner muscle and stromal layers
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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reproductive system
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• canalicular testes located just above the scrotum are more commonly seen
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• unilateral cryptorchidism is rarely seen
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• slight coiling at the anterior end
• reduction of the stromal layer and an increase in luminal branching
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• smaller with a thinner muscle layer
• resembles the more anterior caput segment
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• smaller caudal epididymis
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• typically display coiling of the proximal end
• reduced muscle layer, particularly in the anterior portion
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endocrine/exocrine glands
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• canalicular testes located just above the scrotum are more commonly seen
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• unilateral cryptorchidism is rarely seen
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• all die shortly after birth
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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reproductive system
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• often display an elongated uterotubal junction
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• show some gross coiling of the anterior vas deferens
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• about 26% of females with a vaginal plug fail to produce pups
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• females that do become pregnant have smaller litters
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Analysis Tools