Phenotypes associated with this allele

• Allele Symbol: Zbtb16^tm1Geno
• Allele Name: targeted mutation 1, Genoway
• Allele ID: MGI:5522866
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zbtb16^tm1Geno/Zbtb16^tm1Geno	Not Specified	MGI:5522954

Genotype
MGI:5522954

hm1

• Allelic Composition: Zbtb16^tm1Geno/Zbtb16^tm1Geno
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal male germ cell apoptosis ( J:199097 )

abnormal testis morphology ( J:199097 )

• as in Zbtb16^tm1Ppp homozygotes

cellular

abnormal male germ cell apoptosis ( J:199097 )

abnormal epigenetic regulation of gene expression ( J:199097 )

• expression of L1 retrotransposon is increased compared to in wild-type mice

abnormal DNA methylation ( J:199097 )

• hypomethylation of CpG dinucleotides in Kit, Crabp2 and Myc genes in the bone marrow and testes compared to in wild-type mice

hematopoietic system

abnormal bone marrow cell physiology ( J:199097 )

• bone marrow cells exhibit reduced self-renewal compared with wild-type cells

endocrine/exocrine glands

abnormal testis morphology ( J:199097 )

• as in Zbtb16^tm1Ppp homozygotes