About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trpm2tm1Lhj
targeted mutation 1, Lin-Hua Jiang
MGI:5522800
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trpm2tm1Lhj/Trpm2tm1Lhj Not Specified MGI:5522832


Genotype
MGI:5522832
hm1
Allelic
Composition		 Trpm2tm1Lhj/Trpm2tm1Lhj
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpm2tm1Lhj mutation (0 available); any Trpm2 mutation (109 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal macrophage morphology ( J:202791 )
• macrophages treated with hydrogen peroxide fail to exhibit an increase in extracellular calcium unlike wild-type cells
abnormal macrophage physiology ( J:202791 )
• hydrogen peroxide-treated macrophages exhibit a decrease in the reduction of cell viability compared with wild-type cells

immune system
abnormal macrophage morphology ( J:202791 )
• macrophages treated with hydrogen peroxide fail to exhibit an increase in extracellular calcium unlike wild-type cells
abnormal macrophage physiology ( J:202791 )
• hydrogen peroxide-treated macrophages exhibit a decrease in the reduction of cell viability compared with wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory