Phenotypes associated with this allele

• Allele Symbol: Chek2^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5521536
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Chek2^tm1b(EUCOMM)Hmgu/Chek2^tm1b(EUCOMM)Hmgu Prdm9^tm1Ymat/Prdm9^tm1Ymat	B6.Cg-Chek2^tm1b(EUCOMM)Hmgu Prdm9^tm1Ymat	MGI:6501019

Genotype
MGI:6501019

cx1

• Allelic Composition: Chek2^{tm1b(EUCOMM)Hmgu}/Chek2^{tm1b(EUCOMM)Hmgu}; Prdm9^tm1Ymat/Prdm9^tm1Ymat
• Genetic Background: B6.Cg-Chek2^{tm1b(EUCOMM)Hmgu} Prdm9^tm1Ymat

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased oocyte number ( J:299008 )

♀

reproductive system

decreased oocyte number ( J:299008 )

♀

abnormal chiasmata formation ( J:299008 )

♀ • although there are fewer than normal metaphase oocytes with normal chiasmata between homologous chromosomes, there is a 25% increase compared to mice with wild-type CHEK2

abnormal female meiosis ( J:299008 )

♀

abnormal female meiosis I arrest ( J:299008 )

♀ • P0 oocytes show asynapsis, but to a much less degree than in the presence of CHEK2 and a comparative 3 fold increase in dictyate oocytes

abnormal miscarriage rate ( J:299008 )

♀

reduced female fertility ( J:299008 )

♀ • Background Sensitivity: although there is reduced fertility compared with C57BL/6J controls, compared with Prdm9 null mice wild-type for CHEK2 these double null females produce at least 1 litter in 6 months so have comparatively increased fertility, yet have a high rate of spontaneous abortion and perinatal deaths in pups.