About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sdhbtm1.1Ics
targeted mutation 1.1, Mouse Clinical Institute
MGI:5521531
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ptentm1Mro/Ptentm1Mro
Sdhbtm1.1Ics/Sdhbtm1.2Ics
Tg(KLK3-cre)D4Trp/0 		involves: 129S2/SvPas * BALB/c * C57BL/6 * FVB MGI:5812678
cn2
 		Sdhbtm1.1Ics/Sdhbtm1.1Ics
Tg(Th-cre)12Mrub/0 		involves: 129S2/SvPas * C57BL/6 * CBA MGI:5812672
cn3
 		Sdhbtm1.1Ics/Sdhbtm1.1Ics
Tg(KLK3-cre)D4Trp/0 		involves: 129S2/SvPas * FVB MGI:5812673
cn4
 		Ptentm1Mro/Ptentm1Mro
Sdhbtm1.1Ics/Sdhb+
Tg(KLK3-cre)D4Trp/0 		involves: 129S2/SvPas * FVB MGI:5812676
cn5
 		Ptentm1Mro/Pten+
Sdhbtm1.1Ics/Sdhb+
Tg(KLK3-cre)D4Trp/0 		involves: 129S2/SvPas * FVB MGI:5812679


Genotype
MGI:5812678
cn1
Allelic
Composition		 Ptentm1Mro/Ptentm1Mro
Sdhbtm1.1Ics/Sdhbtm1.2Ics
Tg(KLK3-cre)D4Trp/0
Genetic
Background		 involves: 129S2/SvPas * BALB/c * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Mro mutation (1 available); any Pten mutation (86 available)
Sdhbtm1.1Ics mutation (0 available); any Sdhb mutation (29 available)
Sdhbtm1.2Ics mutation (0 available); any Sdhb mutation (29 available)
Tg(KLK3-cre)D4Trp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased pheochromocytoma incidence ( J:236514 )
• 42% incidence of pheochromocytoma
• tumors do not show accumulation of succinate

neoplasm
increased pheochromocytoma incidence ( J:236514 )
• 42% incidence of pheochromocytoma
• tumors do not show accumulation of succinate




Genotype
MGI:5812672
cn2
Allelic
Composition		 Sdhbtm1.1Ics/Sdhbtm1.1Ics
Tg(Th-cre)12Mrub/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sdhbtm1.1Ics mutation (0 available); any Sdhb mutation (29 available)
Tg(Th-cre)12Mrub mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:236514 )
• mice are viable, fertile and have no apparent phenotype




Genotype
MGI:5812673
cn3
Allelic
Composition		 Sdhbtm1.1Ics/Sdhbtm1.1Ics
Tg(KLK3-cre)D4Trp/0
Genetic
Background		 involves: 129S2/SvPas * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sdhbtm1.1Ics mutation (0 available); any Sdhb mutation (29 available)
Tg(KLK3-cre)D4Trp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:236514 )
• mice are viable, fertile and have no apparent phenotype




Genotype
MGI:5812676
cn4
Allelic
Composition		 Ptentm1Mro/Ptentm1Mro
Sdhbtm1.1Ics/Sdhb+
Tg(KLK3-cre)D4Trp/0
Genetic
Background		 involves: 129S2/SvPas * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Mro mutation (1 available); any Pten mutation (86 available)
Sdhbtm1.1Ics mutation (0 available); any Sdhb mutation (29 available)
Tg(KLK3-cre)D4Trp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased pheochromocytoma incidence ( J:236514 )
• 89% of mice show pheochromocytoma at 12.9 months of age
• tumors do not show accumulation of succinate

neoplasm
increased pheochromocytoma incidence ( J:236514 )
• 89% of mice show pheochromocytoma at 12.9 months of age
• tumors do not show accumulation of succinate

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
pheochromocytoma DOID:0050771 OMIM:171300
 J:236514




Genotype
MGI:5812679
cn5
Allelic
Composition		 Ptentm1Mro/Pten+
Sdhbtm1.1Ics/Sdhb+
Tg(KLK3-cre)D4Trp/0
Genetic
Background		 involves: 129S2/SvPas * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Mro mutation (1 available); any Pten mutation (86 available)
Sdhbtm1.1Ics mutation (0 available); any Sdhb mutation (29 available)
Tg(KLK3-cre)D4Trp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased pheochromocytoma incidence ( J:236514 )
• 64% of mice develop pheochromocytoma

neoplasm
increased pheochromocytoma incidence ( J:236514 )
• 64% of mice develop pheochromocytoma




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory