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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Egln1tm1.1Fsl
targeted mutation 1.1, Frank Lee
MGI:5521374
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Egln1tm1.1Fsl/Egln1tm1.1Fsl C57BL/6-Egln1tm1.1Fsl MGI:5521380
ht2
 		Egln1tm1.1Fsl/Egln1+ C57BL/6-Egln1tm1.1Fsl MGI:5521398
cx3
 		Egln1tm1.1Fsl/Egln1+
Hif1atm3.1Rsjo/Hif1a+ 		B6.Cg-Egln1tm1.1Fsl Hif1atm3.1Rsjo MGI:5525151


Genotype
MGI:5521380
hm1
Allelic
Composition		 Egln1tm1.1Fsl/Egln1tm1.1Fsl
Genetic
Background		 C57BL/6-Egln1tm1.1Fsl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1tm1.1Fsl mutation (1 available); any Egln1 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:202737 )
• heterozygote x heterozygote crosses fail to produce homozygous progeny




Genotype
MGI:5521398
ht2
Allelic
Composition		 Egln1tm1.1Fsl/Egln1+
Genetic
Background		 C57BL/6-Egln1tm1.1Fsl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1tm1.1Fsl mutation (1 available); any Egln1 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased spleen weight ( J:202737 )
• spleen weight is increased as compared to wild-type
polycythemia ( J:202737 )
• mice exhibit erythrocytosis, however, erythropoietin levels are not increased

immune system
increased spleen weight ( J:202737 )
• spleen weight is increased as compared to wild-type

respiratory system
increased tidal volume ( J:202737 )
• under normoxia conditions
increased pulmonary ventilation ( J:202737 )
• under normoxia conditions

growth/size/body
increased spleen weight ( J:202737 )
• spleen weight is increased as compared to wild-type




Genotype
MGI:5525151
cx3
Allelic
Composition		 Egln1tm1.1Fsl/Egln1+
Hif1atm3.1Rsjo/Hif1a+
Genetic
Background		 B6.Cg-Egln1tm1.1Fsl Hif1atm3.1Rsjo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1tm1.1Fsl mutation (1 available); any Egln1 mutation (21 available)
Hif1atm3.1Rsjo mutation (0 available); any Hif1a mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory