Analysis Tools
mortality/aging
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• no mice are present at weaning
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Allele Symbol Allele Name Allele ID |
Mthfd1tm1.1Rzn targeted mutation 1.1, Rima Rozen MGI:5521203 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no mice are present at weaning
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are not viable beyond E10.5
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• at E7.5 and E8.5
• severe at E10.5
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• at E7.5
• size and length at E10.5
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• at E10.5
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• in some mice
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• ruffled or kinked in some mice at E10.5
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• ruffled or kinked in some mice at E10.5
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• few or no somites at E10.5
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• few or no somites at E10.5
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• at E7.5 and E8.5
• severe at E10.5
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• at E7.5
• size and length at E10.5
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• at E10.5
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• in some mice
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• ruffled or kinked in some mice at E10.5
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• ruffled or kinked in some mice at E10.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal levels of methionine and choline metabolites
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• decreased proportion of 10-formyltetrahydrofolate in the plasma
• decreased dihydrofolate levels in the liver of pregnant female mice
• increased methyl-tetrahydrofolate in the liver of pregnant female mice
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• in pregnant female mice
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• in pregnant female mice
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• in female, but not male, mice
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• mouse embryonic fibroblasts exhibit impaired de novo purine synthesis compared with wild-type cells
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• regardless of embryonic genotype, maternal synthetase deficiency increases developmental defects in offspring, including turning defects (caudal torque), craniofacial malformation (asymmetric underdevelopment of the telencephalic vesicle) and abnormal tail and limb bud development
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• in pregnant female mice
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• in pregnant female mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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