reproductive system
N |
• female mice are fertile
(J:202066)
|
N |
• male mice exhibit normal spermatogenesis, sperm morphology and motility and capacitation
(J:202066)
|
• impaired sperm migration from the uterus into the oviduct
|
• severely impaired fertilization in vivo (2.3% vs. 70% of that in control mice)
• however, sperm are able to fertilize cumulus-intact oocytes in vitro
|
• in vitro, sperm are unable to bind zona-intact oocytes
|
cellular
• impaired sperm migration from the uterus into the oviduct
|