Phenotypes associated with this allele

• Allele Symbol: Sema3d^tm1.1Joe
• Allele Name: targeted mutation 1.1, Jonthan Epstein
• Allele ID: MGI:5520920
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sema3d^tm1.1Joe/Sema3d^tm1.1Joe	involves: 129S6/SvEvTac * C57BL/6	MGI:5520921

Genotype
MGI:5520921

hm1

• Allelic Composition: Sema3d^tm1.1Joe/Sema3d^tm1.1Joe
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:198676 )

N • pulmonary endothelial cell proliferation and survival are normal

abnormal pulmonary vein morphology ( J:198676 )

• at E12.5, 4 of 11 mice exhibit abnormal connections of the pulmonary vein to the coronary sinus unlike wild-type mice

• at E17.5, 3 of 8 mice exhibit abnormal connections of the pulmonary vein to the coronary sinus unlike wild-type mice

• the midpharyngeal endothelial strands does not form at the proper location on the dorsal surface of the embryonic common atrium

• abnormal patterning with partial or full penetrance of the pulmonary vein connecting to the coronary sinus (right atrium) or directly to the right atrium

• however, vascular patterning at E9.5 is normal

increased heart right atrium size ( J:198676 )

• massively enlarged

atrial septal defect ( J:198676 )

• in mice with total anomalous pulmonary venous connection

increased heart ventricle size ( J:198676 )

• massively enlarged

left-to-right shunt ( J:198676 )

• left to right shunt with partial or full penetrance of the pulmonary vein connecting to the coronary sinus (right atrium) or directly to the right atrium