Phenotypes associated with this allele

• Allele Symbol: Epas1^tm1.1Fsl
• Allele Name: targeted mutation 1.1, Frank Lee
• Allele ID: MGI:5518445
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Epas1^tm1.1Fsl/Epas1^tm1.1Fsl	involves: C57BL/6 * C57BL/6NTac	MGI:5518458
ht2	Epas1^tm1.1Fsl/Epas1^+	involves: C57BL/6 * C57BL/6NTac	MGI:5518459

Genotype
MGI:5518458

hm1

• Allelic Composition: Epas1^tm1.1Fsl/Epas1^tm1.1Fsl
• Genetic Background: involves: C57BL/6 * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality, incomplete penetrance ( J:199595 )

• fewer than expected mice are present at genotyping

hematopoietic system

increased spleen weight ( J:199595 )

• slightly

increased erythrocyte cell number ( J:199595 )

increased hematocrit ( J:199595 )

increased hemoglobin content ( J:199595 )

increased leukocyte cell number ( J:199595 )

increased monocyte cell number ( J:199595 )

cardiovascular system

pulmonary artery hypoplasia ( J:199595 )

• slight reduction in thickness with non-muscularized arteries

increased heart weight ( J:199595 )

thick ventricular wall ( J:199595 )

• under systole or diastole

abnormal heart right ventricle pressure ( J:199595 )

• age-dependent increase in right ventricular pressure

respiratory system

increased pulmonary respiratory rate ( J:199595 )

• under hypoxic, but not normoxic, conditions

homeostasis/metabolism

increased circulating erythropoietin level ( J:199595 )

immune system

increased spleen weight ( J:199595 )

• slightly

increased leukocyte cell number ( J:199595 )

increased monocyte cell number ( J:199595 )

growth/size/body

increased heart weight ( J:199595 )

increased spleen weight ( J:199595 )

• slightly

Genotype
MGI:5518459

ht2

• Allelic Composition: Epas1^tm1.1Fsl/Epas1⁺
• Genetic Background: involves: C57BL/6 * C57BL/6NTac

hematopoietic system

increased erythrocyte cell number ( J:199595 )

• intermediate

increased hematocrit ( J:199595 )

• intermediate

increased hemoglobin content ( J:199595 )

• intermediate

increased leukocyte cell number ( J:199595 )

increased lymphocyte cell number ( J:199595 )

increased monocyte cell number ( J:199595 )

cardiovascular system

abnormal heart right ventricle pressure ( J:199595 )

• intermediate and age-dependent increase in right ventricular pressure

immune system

increased leukocyte cell number ( J:199595 )

increased lymphocyte cell number ( J:199595 )

increased monocyte cell number ( J:199595 )