Phenotypes associated with this allele

• Allele Symbol: Klk6^tm1Arte
• Allele Name: targeted mutation 1, TaconicArtemis
• Allele ID: MGI:5517797
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klk6^tm1Arte/Klk6^tm1Arte	involves: C57BL/6	MGI:5518422

Genotype
MGI:5518422

hm1

• Allelic Composition: Klk6^tm1Arte/Klk6^tm1Arte
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased oligodendrocyte number ( J:201375 )

• fewer mature oligodendrocytes in the developing spinal cord at P7 without increased apoptosis

• however, the number of mature oligodendrocytes is normal at P14 to P70

abnormal neuron morphology ( J:201375 )

• small-sized neurons, not large-sized motor neurons are prominent in the ventral horn of the spinal cord unlike in wild-type mice

decreased neuron number ( J:201375 )

• fewer NeuN+ neurons in the ventral horn of the spinal cord at P7, but not other time points

• however, the number of Neu+ neurons in the whole spinal cord is normal

homeostasis/metabolism

abnormal response to injury ( J:201375 )

• following spinal cord injury, mice exhibit reduced myelin basic protein expression compared with wild-type mice

• however, mice exhibit normal locomotor function as measured by BMS score after spinal cord injury