Phenotypes associated with this allele

• Allele Symbol: Pip^tm1Myal
• Allele Name: targeted mutation 1, Yvonne Myal
• Allele ID: MGI:5516489
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pip^tm1Myal/Pip^tm1Myal	involves: 129S/SvEv * C57BL/6	MGI:5516577

Genotype
MGI:5516577

hm1

• Allelic Composition: Pip^tm1Myal/Pip^tm1Myal
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

arteritis ( J:202016 )

• cardiac arteritis and periarteritis in one mouse at 13 months

colitis ( J:202016 )

• ulcerative colitis with monocytic and lymphocytic infiltrate in gut-associated lymphoid tissues of the large intestine in one mouse at 13 months

abnormal thymus corticomedullary boundary morphology ( J:202016 )

• loss of distinction in one mouse at 13 months

enlarged thymus medulla ( J:202016 )

• enlarged medulla of the thymus at 3 months

enlarged thymus ( J:202016 )

• enlarged medulla of the thymus at 3 months

enlarged submandibular lymph nodes ( J:202016 )

• containing multiple germinal centers with high mitotic and apoptotic rates at 3 months

cellular

increased apoptosis ( J:202016 )

• in enlarged submandibular lymph nodes at 3 months

increased cell proliferation ( J:202016 )

• in enlarged submandibular lymph nodes at 3 months

reproductive system

abnormal prostate gland dorsolateral lobe morphology ( J:202016 )

• lymphocytic aggregation at 3 months

digestive/alimentary system

abnormal intestinal mucosa morphology ( J:202016 )

• dense infiltration of neutrophils in the mucosa and lamina propria with filamentous bacteria at the luminal surface in one mouse at 13 months

colitis ( J:202016 )

• ulcerative colitis with monocytic and lymphocytic infiltrate in gut-associated lymphoid tissues of the large intestine in one mouse at 13 months

endocrine/exocrine glands

abnormal thymus corticomedullary boundary morphology ( J:202016 )

• loss of distinction in one mouse at 13 months

enlarged thymus medulla ( J:202016 )

• enlarged medulla of the thymus at 3 months

enlarged thymus ( J:202016 )

• enlarged medulla of the thymus at 3 months

abnormal prostate gland dorsolateral lobe morphology ( J:202016 )

• lymphocytic aggregation at 3 months

cardiovascular system

arteritis ( J:202016 )

• cardiac arteritis and periarteritis in one mouse at 13 months

hematopoietic system

abnormal thymus corticomedullary boundary morphology ( J:202016 )

• loss of distinction in one mouse at 13 months

enlarged thymus medulla ( J:202016 )

• enlarged medulla of the thymus at 3 months

enlarged thymus ( J:202016 )

• enlarged medulla of the thymus at 3 months