All Phenotypes Hfe<tm1.1Jrco> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hfe^tm1.1Jrco
targeted mutation 1.1, James Connor
MGI:5516426

Summary

2 genotypes

Allelic Composition	Hfe^tm1.1Jrco/Hfe^tm1.1Jrco
Genetic Background	involves: 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfe^tm1.1Jrco mutation (0 available); any Hfe mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal brain iron level ( J:201948 )

• in the cortex, hippocampus and the cerebellum at 6, but not 12, months

increased liver iron level ( J:201948 )

• at 6 and 12 months

nervous system

astrocytosis ( J:201948 )

abnormal brain iron level ( J:201948 )

• in the cortex, hippocampus and the cerebellum at 6, but not 12, months

growth/size/body

increased body weight ( J:201948 )

• at 6 and 12 months

cellular

astrocytosis ( J:201948 )

oxidative stress ( J:201948 )

• at 6, but not 12, months

liver/biliary system

increased liver iron level ( J:201948 )

• at 6 and 12 months

Allelic Composition	Hfe^tm1.1Jrco/Hfe⁺
Genetic Background	involves: 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfe^tm1.1Jrco mutation (0 available); any Hfe mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

oxidative stress ( J:201948 )

• at 6, but not 12, months

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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