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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mrm3tm1.1(KOMP)Vlcg
targeted mutation 1.1, Velocigene
MGI:5516076
Summary 3 genotypes


Genotype
MGI:6377030
hm1
Allelic
Composition
Mrm3tm1.1(KOMP)Vlcg/Mrm3tm1.1(KOMP)Vlcg
Genetic
Background
B6N(Cg)-Mrm3tm1.1(KOMP)Vlcg/J
Cell Lines 13785A-E7
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mrm3tm1.1(KOMP)Vlcg mutation (1 available); any Mrm3 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygous embryos are recovered at expected Mendelian ratios at E7.5 but stall in development at ~E8.0
• no homozygous embryos are recovered at E9.5

embryo
• embryos stall in development at ~E8.0 and are significantly delayed by E8.5
• however, most morphological features typical of E7.5 are present
• embryos appear slightly smaller than controls at E7.5

growth/size/body
• embryos stall in development at ~E8.0 and are significantly delayed by E8.5
• however, most morphological features typical of E7.5 are present
• embryos appear slightly smaller than controls at E7.5




Genotype
MGI:5757650
hm2
Allelic
Composition
Mrm3tm1.1(KOMP)Vlcg/Mrm3tm1.1(KOMP)Vlcg
Genetic
Background
C57BL/6N-Mrm3tm1.1(KOMP)Vlcg/J
Cell Lines 13785A-E7
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mrm3tm1.1(KOMP)Vlcg mutation (1 available); any Mrm3 mutation (19 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5759439
ht3
Allelic
Composition
Mrm3tm1.1(KOMP)Vlcg/Mrm3+
Genetic
Background
C57BL/6N-Mrm3tm1.1(KOMP)Vlcg/J
Cell Lines 13785A-E7
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mrm3tm1.1(KOMP)Vlcg mutation (1 available); any Mrm3 mutation (19 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism

nervous system

skeleton





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory